Endocrine Abstracts

Introduction: The uncertainty surrounding the optimal dose to rectify severe vitamin D deficiency (VDD) necessitates further investigation.Aim: To review and analyze various vitamin D (VD) supplementation doses, durations, and their effects on 25-hydroxyvitamin D (25OHD) levels, along with their biochemical and clinical outcomes, in the management of VDD.Methods: We reviewed intervention studies targeting VDD from databases (PubMed...

Introduction: The relationship between early puberty and abnormal bone health has garnered significant research attention, with varying outcomes. Objectives: This review systematically examines studies up to March 2023 to determine whether early puberty is associated with abnormal bone health, specifically low bone mineral density (BMD), osteopenia, and osteoporosis. We analyze and summarize research articles (n=25) to elucidate the potential li...

We conducted a longitudinal study on 95 children presented to pediatric clinic with short stature. Children were classified to low IGF1 (IGF1SDS <-1) (n=25) and normal IGF1 (IGF1SDS >-1) (n=70) and treated with human GH (0.03: 0.05 mg/kg/day) for 2 years. Anthropometrics data (HtSDS, difference from mid-parental height SDS (MPHSD), BMISDS, bone age and IGF1 level were studied for 2 years.Results: At presentation, the age, bone a...

The Relationship between Precocious/Early Puberty and Obesity with Metabolic Abnormalities: A Comprehensive ReviewIntroduction: The impact of pubertal timing on the development of obesity and metabolic abnormalities has been the subject of extensive research with variable outcomes. Objective: We systematically reviewed studies (Medline, Pubmed, Google scholar, and Web of Science) 2000 until March 2023 evaluating the relation betwee...

This study aimed to explore the prevalence of distinct Metabolic Syndrome (MetS) components and plasma AIP among obese children and adolescents, and to evaluate their anthropometric measures in comparison to their parents, thereby considering genetic and environmental influences.Methodology: Anthropometric and biochemical profiles of 91 randomly selected obese children and young adolescents (mean age: 10.5&pm;2.7 years) were meticulously analyzed. This c...

Introduction: The contribution of reproductive factors to breast cancer (BC) susceptibility requires further investigation. This study aims to explore the potential link between early puberty (menarche) and the risk of breast cancer in women.Aim: This study systematically reviews research conducted between 2000 and March 2023, aiming to evaluate the association between early/precocious puberty and the incidence of BC.Methods: A com...

Background: Pituitary microadenomas in pediatric populations, though infrequent, present diagnostic and therapeutic challenges.Methods: We retrospectively reviewed six pediatric cases of pituitary microadenomas diagnosed and treated at our institution. The cases were analyzed for presenting symptoms, hormonal profiles, and treatment responses.Results: Case 1: A 12-year-old with growth hormone deficiency showed significant height im...

Introduction: This review aims to systematically analyze and summarize the findings from research articles regarding the potential short-term and long-term side effects of L-thyroxine therapy in children and adolescents. The selection criteria for the studies included their focus on the negative effects of thyroxine therapy related to thyroid health, cognitive function, cardiovascular health, bone health, and cancer risk in pediatric populations. Results...

Pituitary microadenomas in children and adolescents are relatively rare, accounting for a small percentage of pediatric endocrine disorders. These benign tumors often present a diagnostic challenge due to their subtle and variable clinical manifestations at this young age. We present clinical and lab data of 5 children with pituitary microadenoma. Case 1: A 12-year-old female with a history of short stature and slow growth velocity was diagnosed with a small pituitary microade...

To investigate the best criteria and time to diagnose dysglycemia in β-TM patients, the ICETA performed a retrospective study on glycemic abnormalities (GD) in 397 with β-TM patients (aged 5–40 years; 56.3% males) followed between 1988 to 2021 in a single centre (by VDS) (40 years).Methods: Fasting blood glucose (FPG) and standard oral glucose tolerance test (OGTT) results were collected over 40 years of follow up and results were categori...